Many may fantasize about becoming astrologers, tarot readers, mediums, empaths, or any other kind of spiritual entrepreneur, and wonder when is the right time to do so. First, if your gut is telling you to, then it's probably the right time for you (listen to your instincts!). In general, change-maker Uranus now in money-maker Taurus can create conditions for many to change the way they make money (and with Uranus ruling astrology specifically, more may be focused on trying to become profitable astrologers!).
On a personal level, you can look at aspects being made to your natal and progressed charts. Much of what you'll look for will be similar to as if you were looking for any other career aspects - positive aspects (sextiles and trines) by Saturn, Uranus, Neptune, and Pluto to your 2nd house cusp or ruler (house of money), 6th house cusp or ruler (house of work), and 10th house cusp or ruler (house of career), or to your natal Saturn (planet of career). Any aspect by Uranus (including hard ones) to these points can indicate a change in profession (and the hard aspects are actually super helpful for when you want to make a big change and have felt so stuck or afraid of change that you haven't gotten anywhere thus far). The progressed Midheaven at a critical degree or moving into a new sign can also signal new career developments, and any progressed planet moving into a new sign or a progressed new moon can be excellent for any kind of new beginning in your life (like new work!).
For spiritual work in particular, there will often be some Neptune, 12th house, or Pisces involved as these are the spiritual points. Positive aspects to your natal Neptune, your natal or progressed 12th house cusp or ruler, or to natal or progressed Pisces planets can stimulate extra focus on your spiritual self, and guide you toward this kind of work when occurring with other career aspects. Aspects can transit Neptune can also do this, though with the hard aspects, you may have to watch for being drained too much by the work or attracting people who want to take advantage of you (so have those healthy boundaries Neptune requires!). Progressed planets moving into Pisces or your natal 12th house, aspecting your natal Neptune, or your progressed 12th house cusp conjunct, sextile, or trine a natal planet can also bring spiritual focus.
Being a spiritual entrepreneur is a job, so it can be a lot of work! But it can also be very rewarding if you feel called to it. Good luck!
P.S. You may also want to check out the So You Wanna Be An Astrologer series - Part 1, Part 2, Part 3, and Part 4
Jupiter Conjunct Pluto 2020
Saturn Conjunct Pluto 2020
Mercury Retrograde in Pisces & Aquarius: February - March 2020
March 2020 New & Full Moons
April 2020 New & Full Moons
Jupiter in Capricorn: December 2019 - December 2020
Saturn in Aquarius: March - July 2020, December 2020 - March 2023
Saturn in Capricorn: December 2017 - March 2020, July - December 2020
Uranus in Taurus: May - November 2018, March 2019 - July 2025, November 2025 - April 2026