Neptune and Pluto are generational planets, taking many years to go through a sign. In the natal chart, their house position is usually more important for each individual than the sign position as a result. Neptune's location tends to show areas where you experience the least mental focus, the most foggy thinking. Neptune isn't very clear-headed and loves dreams, illusions, delusions, so you can be prone to not seeing things clearly with those areas. Pluto is not so foggy, Pluto is powerful and shows areas we have the most power or experience the most power/control issues in life. He's also transformative, so his location can show where we must undergo many transformations in our lives.
In prediction, Neptune can show where our thinking is less clear, and we're not able to see the full details in situations. Neptune also has a "dissolving" energy, so he can also bring dissolvement in the areas of life related to where he's transiting. Pluto is transforming, and sometimes to the point of ripping apart everything in your life (especially in the 1st house, 2nd house, or making a harsh aspect to your Sun or Moon). Pluto wants change, demands change, in the name of developing more power and control. Transform the areas of life ruled by where Pluto's going through, otherwise he'll do it for you.
Neptune rules Pisces and the 12th house; Pluto rules Scorpio and the 8th house.
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